Marcus Groettrup Selected Research

PR-957

1/2022	Effective therapy of polymyositis in mice via selective inhibition of the immunoproteasome.
1/2022	Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation.
12/2018	Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity.
1/2018	Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis.
8/2017	Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice.
1/2016	Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.
1/2014	Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.
10/2012	Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation.
7/2009	A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

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Marcus Groettrup Research Topics

Disease

24	Neoplasms (Cancer) 11/2021 - 08/2002
11	Infections 01/2021 - 09/2004
10	Autoimmune Diseases (Autoimmune Disease) 11/2021 - 10/2012
8	Inflammation (Inflammations) 01/2022 - 07/2010
5	Carcinoma (Carcinomatosis) 01/2021 - 12/2006
5	Colitis 12/2018 - 07/2010
4	Virus Diseases (Viral Diseases) 01/2021 - 04/2004
4	Disease Progression 11/2020 - 01/2007
4	Prostatic Neoplasms (Prostate Cancer) 04/2016 - 09/2005
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2018 - 02/2013
3	Weight Loss (Weight Reduction) 01/2018 - 07/2010
2	Neoplasm Metastasis (Metastasis) 01/2021 - 10/2016
2	Multiple Myeloma 11/2020 - 11/2009
2	Blindness (Hysterical Blindness) 10/2020 - 01/2012
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 07/2014 - 01/2013
2	Rheumatoid Arthritis 03/2013 - 07/2009
2	Human Influenza (Influenza) 08/2012 - 12/2006
1	Myositis (Idiopathic Inflammatory Myopathies) 01/2022
1	Muscle Weakness 01/2022
1	Polymyositis 01/2022
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Eye Diseases (Eye Disease) 10/2020
1	Breast Neoplasms (Breast Cancer) 02/2020
1	Persistent Infection 01/2019
1	Colitis-Associated Neoplasms 01/2019
1	ZAP70 deficiency 01/2018
1	Colonic Neoplasms (Colon Cancer) 01/2018
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2018
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018
1	Melanoma (Melanoma, Malignant) 10/2017
1	Body Weight (Weight, Body) 08/2017
1	Carcinogenesis 08/2017
1	Colorectal Neoplasms (Colorectal Cancer) 08/2017
1	Glioma (Gliomas) 10/2016
1	Stomach Neoplasms (Stomach Cancer) 10/2016
1	Systemic candidiasis 01/2016
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2015
1	Communicable Diseases (Infectious Diseases) 10/2015
1	Meningitis 01/2015
1	Pain (Aches) 01/2015
1	Wounds and Injuries (Trauma) 07/2014
1	Multiple Sclerosis 03/2013
1	Alzheimer Disease (Alzheimer's Disease) 12/2012
1	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2012

Drug/Important Bio-Agent (IBA)

12	AntigensIBA 01/2021 - 03/2003
11	CytokinesIBA 01/2019 - 07/2009
9	PR-957IBA 01/2022 - 07/2009
9	EpitopesIBA 11/2015 - 09/2004
8	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 09/2004
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2004
6	VaccinesIBA 01/2021 - 08/2002
6	Peptides (Polypeptides)IBA 01/2021 - 04/2004
4	Pharmaceutical PreparationsIBA 01/2021 - 10/2012
4	Polylactic Acid-Polyglycolic Acid CopolymerIBA 01/2021 - 05/2011
3	LigandsIBA 01/2021 - 08/2012
3	Proteasome InhibitorsIBA 11/2020 - 11/2009
3	Interleukin-23 (Interleukin 23)IBA 10/2019 - 03/2013
3	Neoplasm Antigens (Tumor Antigens)IBA 01/2019 - 03/2003
3	Cancer VaccinesIBA 01/2019 - 08/2012
3	Interleukin-6 (Interleukin 6)IBA 12/2018 - 01/2013
3	DNA (Deoxyribonucleic Acid)IBA 09/2012 - 01/2011
3	Hormones (Hormone)IBA 01/2007 - 09/2005
2	OvalbuminIBA 01/2022 - 03/2008
2	InterferonsIBA 01/2019 - 02/2013
2	Messenger RNA (mRNA)IBA 01/2019 - 01/2008
2	Dextran SulfateIBA 01/2018 - 07/2010
2	UbiquitinIBA 10/2016 - 01/2012
2	HLA-A*02:01 antigenIBA 04/2016 - 12/2006
2	Histocompatibility Antigens Class IIBA 01/2016 - 11/2009
2	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 11/2009 - 12/2006
2	prostatic acid phosphataseIBA 01/2007 - 12/2006
1	Therapeutic UsesIBA 01/2022
1	KZR-616IBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2021
1	Retinaldehyde (Retinal)IBA 10/2020
1	glidobactin CIBA 02/2020
1	PolymersIBA 01/2019
1	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 01/2018
1	Interleukin-17 (Interleukin 17)IBA 08/2017
1	Transcription Activator-Like Effector NucleasesIBA 12/2016
1	CateninsIBA 10/2016
1	Buprenorphine (Subutex)FDA LinkGeneric 01/2015
1	Dinoprostone (PGE2)FDA Link 03/2013
1	PolyubiquitinIBA 02/2013
1	Ubiquitinated ProteinsIBA 02/2013
1	Interleukin-8 (Interleukin 8)IBA 01/2013
1	Monocyte Chemoattractant ProteinsIBA 01/2013
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013
1	Interleukin-10 (Interleukin 10)IBA 01/2013
1	InterleukinsIBA 01/2013
1	LipopolysaccharidesIBA 01/2013
1	Protein AggregatesIBA 12/2012

Therapy/Procedure

14	Immunotherapy 01/2021 - 08/2002
8	Therapeutics 01/2022 - 03/2003
7	Microspheres (Microsphere) 01/2019 - 05/2011
3	Radiotherapy 01/2019 - 01/2007
2	Transplantation 11/2021 - 01/2019
2	Drug Therapy (Chemotherapy) 01/2019 - 01/2011
1	Analgesia 01/2015